Protium section Pepeanthos, a neotropical group of nine species ranging from Costa Rica to the southern perimeter of Amazonia, is described, as are the group's five new species: P. calendulinum, P. gallosum, P. pecuniosum, P. retusum, and P. urophyllidium. Keys are provided to flowering and to fruiting material. The new section is characterized by a milky resin; lateral leaflet pulvinuli inconspicuous or absent; style short-branched and the stigmas caudiculate and spiculate; and the cotyledons plano-convex.